The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity
نویسندگان
چکیده
منابع مشابه
Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma.
Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial collagenases and MMP-9. TIMP-2 binds specifically and noncovalently to the pro-form of MMP-2 and inhibits its enzyme activity. In this study, we examined TIMP-...
متن کاملExpression of Tissue Inhibitors of Metalloproteinases (TIMPs) in Hepatocellular Carcinoma
BACKGROUND Matrix metalloproteinases (MMPs) have been implicated in the remodelling of extracellular matrix (ECM), including basement membrane. ECM remodelling is associated with pathological processes, including hepatic fibrosis, tumor invasion and metastasis. Tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 were known to inhibit MMP-9 and MMP-2, respectively. In the present study, w...
متن کاملExpression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis
Tissue inhibitors of matrix metalloproteinases (TIMPs) regulate the breakdown of extracellular matrix components and play an important role in tissue remodelling and growth, in both physiological and pathological conditions. We studied the autoimmune response to TIMPs in patients with rheumatoid arthritis (RA). Eighty-nine paired blood and synovial fluid samples from patients with RA were asses...
متن کاملPlant Pin-II Family Proteinase Inhibitors: Structural and Functional Diversity
Potato inhibitor II (Pin-II) proteins are plant serine proteinase inhibitors (PIs) that occur in various plant species. Pin-II PIs are characterized by inhibitory repeat domains (IRDs) which form their functional units and show extensive sequence variation. Various studies have been conducted to gauge the occurrence (spatial and temporal) of Pin-II PIs and their appearance in response to biotic...
متن کاملRole of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail.
Pericellular proteolysis represents one of the key modes by which the cell can modulate its environment, involving not only turnover of the extracellular matrix but also the regulation of cell membrane proteins, such as growth factors and their receptors. The metzincins are active players in such proteolytic events, and their mode of regulation is therefore of particular interest and importance...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2010
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2010.01.003